Remifentanil combined with midazolam effects on learning and memory in mice.doc

 PAGE \* MERGEFORMAT 8 Remifentanil combined with midazolam effects on learning and memory in mice Of: Songsu Pei, Dong Li, TRUTH, Wei Zheng, Ti-Jun Dai [Abstract] Objective To observe the Charui fentanyl and midazolam combined with learning and memory in mice. Methods stratified random block design by the mice were divided into 3 groups: remifentanil + saline (R) group, Midazolam + saline (M) group, the remifentanil + midazolam (RM) group. with the jumping test were used to observe the latency period and number of errors to assess the drugs on learning and memory function. Results on day 1 after treatment, compared with the R, RM group latency, the number of errors increased (P lt;0.01, P lt;0.05, compared with the M RM group increased the number of errors (P lt;0.05, after treatment 2 days, compared with the R, RM latency group, the number of errors increased (P lt;0.05, 3 days after treatment, the latency and the number of errors between the groups was no significant difference (Pgt; 0.05. Conclusions remifentanil too Nepal combination with midazolam can strengthen the role of damage to learning and memory in mice, but does not cause lasting learning and memory disorders. [Keywords:] remifentanil, midazolam, step down test, learning and memory Awareness during anesthesia (referred to as intraoperative awareness) is an unpleasant experience that can bring patients with different degrees of mental impairment [1]. Remifentanil (remifentanil, R) and midazolam (midazolam, M is anesthesia commonly used in clinical medicine. Remifentanil is a new opioid analgesic short time, with a smooth anesthesia, metabolism is not dependent on kidney function, continuous infusion of no savings, etc., and thus superior to the traditional opioid [ 2]. midazolam for the benzodiazepine class of sedative-hypnotics Lv Zhuo, intravenous injection of rapid onset, short duration, bioavailability, no significant savings to the phenomenon [3]. midazolam can produce amnesia [ 4