Resolution of chiral drugs Research Progress.doc

 PAGE \* MERGEFORMAT 26 Resolution of chiral drugs Research Progress Author: Lu Ding-Qiang Li Xiu Ling Yan-Liang Chen Jia-quan Tu Shiba [Abstract] brief description of chiral drugs in the world sales market. An overview of current laboratory and industrial production of chiral drugs splitting methods, including: crystal split method, chemical splitting method, kinetic resolution method, bio-split method, chromatography split method, chiral extraction Split Law and membrane break laws, and briefly describes the application of each method and the advantages and disadvantages. [Keywords:] chiral drugs; raceme; chiral separation Abstract: In this paper, the global market of chiral drugs were summarized. Chiral resolution techniques were briefly reviewed according to recent references, both those already in commercial practice and emerging technologies in labs, including crystallization, chemical, ferment, chromatographic, chiral extraction and membranous. The merit and defect of every methods were discussed. Keywords:: Chiral drug; Raceme; Chiral separation There is a wide variety of chiral natural phenomena, such as proteins, amino acids, polysaccharides, nucleic acids, enzymes and an important basis for the material life activity, are hand in nature. According to statistics, 1,200 new drugs in research and development, there are 820 kinds of hand in nature, accounting for 68% of the world’s development of new drugs for more than [1]. The United States FDA in 1992 released the guiding principles of chiral drugs, the principle requires that all pharmaceutical companies developing new drugs in the future, we must explicitly quantify the enantiomers of each role and efficacy of toxicological effects, and when the two kinds of heterogeneous significantly different from the role of body must be listed on the form of optically pure drugs. Followed by the EC and Japan have also taken corresponding measures. This measure greatly facilitated Resolution of chiral dr