Related acute lung injury and lung AQP5 Study.doc

 PAGE \* MERGEFORMAT 12 Related acute lung injury and lung AQP5 Study Acute lung injury (acute lung injury, ALI) and acute respiratory distress syndrome (acute respiratory distres syndrome, ARDS) is a severe infection, trauma, shock, and aspiration and other causes of acute lung injury. The main pathophysiological changes of diffuse, non-uniformity of the alveoli, alveolar capillary membrane injury, alveolar protein-rich inflammatory exudate, leading to pulmonary edema and pulmonary micro-thrombosis, clinical manifestations of respiratory distress and stubborn hypoxemia syndrome. Inflammatory cells, inflammatory mediators and associated cell signaling pathway, and is closely related acute lung injury. Water channel protein (aquaporin, AQP) is responsible only for transport of water, without allowing the other solute, and molecules to pass through, in the alveolar fluid absorption plays an important role in the transmembrane protein, as the differentiation of alveolar epithelial cells type Ⅰ a sign of function of the channel at least involved in water transport, participation gland secretion, participate in airway hyper-responsiveness and so on. At the same time, we can correspond with the functional inspection of the literature to the various types of acute lung injury: LPS caused acute lung injury, viral infection can cause acute lung injury, high oxygen-induced lung injury, as well as AQPS of respiratory airway surface liquid (airway surface liquid, ASL) the role and regulation, it’s always with AQP5 plays an important role. The discovery of water channel proteins of ALI jumping into a new phase, it found that enable us to ALI at the molecular level understanding of the occurrence and development of the entire process. But are primarily used transgenic mice to AQPS functional studies, and transgenic mice compensate for changes in organ function that may arise, and germ-line differences. And the right awareness of lung water channel