Rhabdomyolysis syndrome and acute renal injury in Progress.docVIP

 PAGE \* MERGEFORMAT 20 Rhabdomyolysis syndrome and acute renal injury in Progress [Abstract] Objective With the constant awareness of rhabdomyolysis syndrome, found that the most important complications of acute kidney injury, hyperlipidemia clinic to myoglobin, myoglobinuria, acute tubular necrosis as the main feature, the prognosis is ominous high mortality rate. In this paper, rhabdomyolysis syndrome and acute renal injury epidemiology, etiology, pathogenesis, clinical features and control methods are reviewed. [Keywords:] myoglobin rhabdomyolysis syndrome, acute kidney injury in creatine kinase Rhabdomyolysis syndrome (rhabdomyolysis, RM means that when the muscle trauma, ischemia, inflammation, metabolic disorders or systemic poisoning, injury and other factors that change the integrity of striated muscle cell membrane, leakage of cellular contents, including myoglobin (myoglobin, Mb , creatine kinase (creatine phosphokinase, CPK and other enzymes and ion and small molecule toxic substances released into the blood, causing a change in the clinical syndrome and test indicators. often associated with life-threatening metabolic disorders and acute kidney injury ( acute kidney injury, AKI). AKI refers to the abnormal kidney structure and function (including blood, urine and tissue tests or imaging markers of renal injury in terms of an exception), no more than 3 months. The diagnostic criteria were: renal function sharp decline in serum creatinine within 48 hours before injury increased 1.5 times or increase 26.5umol / L, and (or) urine output lt;0.5ml/kg h, for 6 hours or more. Rhabdomyolysis caused by acute tubular necrosis syndrome is an important one of the reasons, lack of knowledge over the last people to it, clinical reports less level with the continuous improvement of diagnosis, the disease incidence and increasing coverage. In this paper, comprehensive rhabdomyolysis symptoms of acute kidney injury epidemiology, etiology, pathog