Research the causes of gall bladder stones.docVIP

 PAGE \* MERGEFORMAT 6 Research the causes of gall bladder stones Gallbladder stones has become a serious problem affecting human health and disease, its incidence was rising trend. From the world-wide perspective, 70% ~ 80% for cholesterol gallstone stones [1]. For gallbladder stones, particularly cholesterol gallstone study of the causes of biliary tract surgery became hot. After 40 years of exploration, this research has moved from the initial pairs of gallstone and bile analysis of physical and chemical properties, in-depth into the molecular biology, genetics and other fields. Recent studies have focused on cholesterol metabolism, ‘lithogenic genes’ identification and so on. This paper studies the progress made in recent years to make the following overview. An ‘environmental illness’ and ‘genetic disease’ Epidemiological investigation showed that the cholesterol gallstone incidence there is a big difference between the different races [2]. Nakeeb et al [1] on a group of unrelated individuals to conduct a joint study found that a positive family history of relatives cholecystectomy cholesterol gallstone disease is a significant risk factor. Recently, Katsika et al [3] For the 43 years 1900-1958 was born in 141 pairs of Swedish twins statistical analysis found that monozygotic twins of the incidence of symptomatic gallbladder stones consistency and relevance of the eggs were significantly higher than pairs of twins and there are no gender differences. They arrive at the statistics of the incidence of symptomatic gallbladder stones factors, genetic effects accounted for 25% of the environmental factors alone accounted for 62%. These studies indicate that gallbladder stones are a variety of genes with environmental factors determined the complex role of this institution. Caused by the presence of stone gene was confirmed in animal experiments. A variety of natural strains of rats with different blood cholesterol levels and gallstone susceptibility. Decide