Rhubarb worm pill on the formative stages of pulmonary fibrosis in lung tissue expression of TNF.doc

 PAGE \* MERGEFORMAT 15 Rhubarb worm pill on the formative stages of pulmonary fibrosis in lung tissue expression of TNF Of: Rui-Qin Li, Song Jianping, Li Wei, Zhang Rui, Zhang Limin, Zhang Xian-Wei [Abstract] Objective To investigate the rhubarb pest control pill and mechanism of pulmonary fibrosis. Methods Bleomycin induced pulmonary fibrosis, the first 14 days of starting treatment group fed rhubarb worm pill every day, 28 days after the death of the rats, observed and compared the rats histological changes of lung and lung tissue tumor necrosis factor-@ (TNF-@ expression. Results of lung fibrosis model group, the lung tissue expression of TNF-@ was higher than the control group and treatment group (P lt;0. 05). Conclusion Rhubarb can significantly reduce worm pill Bleomycin-induced pulmonary fibrosis in lung tissue and can inhibit the overexpression of TNF-@. [Keywords:] pulmonary fibrosis, tumor necrosis factor-@, rhubarb pills insects, rats Pulmonary Fibrosis is the development of a variety of interstitial lung disease to a common pathological changes later. Although for different reasons lead to pulmonary fibrosis, but the pathological changes are starting from alveolitis. Is generally believed that lung fibrosis is not reversible Western medicine treatment of pulmonary fibrosis, corticosteroids choice, but only parts such as nonspecific interstitial pneumonia (NSIP and desquamative interstitial pneumonia (DIP so good on the hormonal responses, on the other long-term high-dose corticosteroids will lead to serious metabolic disorders, immune suppression and secondary infection and other adverse reactions, so the study of drug prevention and treatment of pulmonary fibrosis pulmonary scientific community is increasingly becoming an international hot spot of concern. In recent years many reports of Chinese medicine treatment of pulmonary fibrosis, and achieved gratifying results have been Chinese Medical Association to be included in the preventi