Respiratory syncytial virus infection and asthma.docVIP

 PAGE \* MERGEFORMAT 18 Respiratory syncytial virus infection and asthma Author: Wong Kam Tong, Xu Huiqin, FAN Xin Health [Keywords:] respiratory syncytial virus, asthma, The nature of asthma is a chronic non-specific inflammation, with genetic factors and environmental factors. In recent years, an increasing number of observations suggest that in the formation and repeated asthma attacks, respiratory virus infections play an important role, in which the incidence of asthma with people is the most closely related respiratory syncytial virus (RSV) infection. 1 Epidemiology In recent years, using RT-PCR with serology and virus culture, confirmed that 80% of U.S. children aged 9 to 11 communities and 50% to 55% of adult asthma and viral infections [1]. Obviously respiratory virus infections are caused by an asthma attack in children and adults the main reason. In infants and young children the most common respiratory virus is RSV, 50% of the asthmatic disease and 80% of the occurrence of bronchiolitis and RSV infection. Acute RSV infection in infancy is not only can cause recurrent wheezing and asthma form a close relationship with the future. Almost all children 3 years of age infected with RSV before they are triggered by breathing, but only some children develop into asthma. Reduced lung function in infants and family smoking is breathing space to develop into an important risk factor for asthma [2]. In addition the specificity of infants and young children constitution, there is a history of eczema or allergic rhinitis, serum total IgE or antigen-specific IgE increased and family history of allergies, particularly in the mother’s history of asthma, are infected with RSV develop into a risk factor for asthma [3] . RSV infection can also directly induce or aggravate asthma. 1997, Robinson et al [4] confirmed that RSV infection in guinea pigs, at least 6 weeks of airway responsiveness in guinea pigs was significantly higher. 2003 Makela et al [5] found