Risperidone quetiapine aripiprazole on glucose and lipid metabolism in patients with schizophrenia.doc

 PAGE \* MERGEFORMAT 11 Risperidone quetiapine aripiprazole on glucose and lipid metabolism in patients with schizophrenia [Abstract] Objective: To investigate the risperidone, quetiapine, aripiprazole on glucose and lipid metabolism in patients with schizophrenia. Methods: 99 patients hospitalized with schizophrenia were divided into 3 groups, respectively, risperidone, quinoline quetiapine, aripiprazole treatment for 8 weeks, fasting blood glucose before and after treatment, two-hour postprandial blood glucose and fasting lipids (triglycerides). Results: Houli Pei ketone group, the patients in quetiapine group of triglyceride level [(1.46 + -0.72) mmol / L, (1.40 + -0.65) mmol / L] higher than before treatment [(0.87 + -0.37) mmol / L, (1.24 + -0.70) mmol / L], the difference statistically significant (P lt;0.05); blood glucose levels before and after treatment in both groups no significant difference (Pgt; 0.05). aripiprazole blood glucose, blood lipid levels before and after treatment was no significant difference (Pgt; 0.05). Conclusion: taking risperidone, quetiapine can affect lipid metabolism, aripiprazole had no significant effect on glucose and lipid metabolism. [Keywords:] Risperidone; quetiapine; aripiprazole; glucose; lipid [Abstract] Objective: To evaluate the effects of risperidone, quetiapine and aripiprazole on the glucose and lipid metabolism of patients with schizophrenia. Methods: Ninty nine patients with schizophrenia were divided into risperidone group, quetiapine group, and aripiprazole group. The fasting glucose, 2 hour plasma glucose and fasting triglyceride were measured before and 8 weeks after drug administration. Results: The triglyceride levels in risperidone group and quetiapine group were significantly increased after drug administration [(1.46 + -0.72) mmol / L vs (0.87 + -0.37 ) mmol / L; (1.40 + -0.65) mmol / L vs (1.24 + -0.70) mmol / L, respectively] (P lt;0.05), but unchanged in the glucose levels (Pgt; 0.05). The