Rutin in different media Determination of equilibrium solubility.doc

 PAGE \* MERGEFORMAT 9 Rutin in different media Determination of equilibrium solubility Author: Zhong Ling Zang Chi and Wu Min LIAO Chang-jun CHEN Ke [Abstract] Objective determination of rutin in water, 0.1 mol * L-1 HCl and phosphate buffer of different pH values in the equilibrium solubility. Methods Determination of Rutin by UV spectrophotometry in water, 0.1 mol * L-1 HCl and phosphate buffer concentration. Results at 37 ℃ and rutin solubility in water balance of 194.57 mg * L-1; in 0.1 mol * L-1 HCl in the equilibrium solubility of 173.08 mg * L-1; in phosphate buffer solution with pH buffer value increased (2.5-7.8), its solubility by 55.48mg * L-1 increase to 521.08 mg * L-1. Conclusion rutin very slightly soluble in water; rutin solubility by the medium pH, high-impact. [Keywords:] Rutin equilibrium solubility by UV spectrophotometry Rutin is a flavonoid, a typical representative of the widely found in nature, almost all of the Rutaceae and evergreen plants contain rutin Division. Rutin in mind the treatment of cerebral vascular diseases play a pivotal role, primarily for the treatment of capillary fragility and permeability of blood can reduce the body’s blood fat and cholesterol, the treatment of hypertension, cardiovascular disease, diabetes and other chronic disease, medicine [1]. At present, the clinical application of rutin oral preparations is mainly ordinary tablets, there are frequent administration problems. Development of rutin sustained and controlled release preparations, can reduce the dose frequency, improve patient medication compliance, especially for long-term medication in patients with chronic diseases. In this study, choice of water, 0.1 mol * L-1 HCl and pH 2.5 ~ 7.8 phosphate buffer as the solvent, simulated gastrointestinal fluid acid-base environment, rutin in the above equilibrium solubility in different media were determined, in order to develop Lu Ding slow release formulation of new dosage forms, as well as its