Rutin osmotic pump tablet method of in vitro release.doc

 PAGE \* MERGEFORMAT 15 Rutin osmotic pump tablet method of in vitro release [Abstract] Objective To establish the osmotic pump tablets of rutin in vitro release method. Method effects of different dissolution methods, media and impeller speed of dissolution of rutin in vitro release osmotic pump tablets effects of UV spectrophotometry with rutin and with different ratios of rutin osmotic pump tablets prescription products for determination of in vitro release differences. The results of the pH value of dissolution medium, dissolution methods and impeller rotational speed of osmotic pump tablets of rutin no significant effect on release behavior to determine the release of media types and sizes, and the impeller speed of dissolution methods, the establishment of osmotic pump tablets of rutin in vitro release testing methods and can measure the different proportions of rutin osmotic pump tablets prescription products between in vitro release. Conclusion Determination of release to establish effective screening of the materials can be used for prescription optimization. [Keywords:] rutin, osmotic pump tablets, in vitro release Drug in vitro release of drug from sustained release formulation means, controlled release formulations, enteric-coated formulations and transdermal agent under specified conditions attached release rate and extent of drug formulations to evaluate the intrinsic quality of indicators is an important quality control preparation means. rutin to quercetin 3-O-rutinoside, a wide range of pharmacological effects [1,2], clinical used to prevent stroke, hypertension and other cardiovascular diseases. rutin presence of oral administration of ordinary tablets frequent problem, Development rutin oral osmotic pump tablets, can reduce the dose frequency and improve patient medication compliance. rutin osmotic pump tablets in vitro release method of study is the formulation design and optimization of the important guarantee. this experiment Ruti