Rosiglitazone on the diabetic rat heart aquaporin 1 expression.docVIP

 PAGE \* MERGEFORMAT 10 Rosiglitazone on the diabetic rat heart aquaporin 1 expression Of: WANG Hai-ying Chen Baoqin handsome solution [ABSTRACT] Objective of rosiglitazone on diabetic rat heart aquaporin 1 (AQP1) expression, of rosiglitazone on myocardial lesions in rats with early diabetes intervention. Methods to just type 2 diabetic model the rats were randomly divided rosiglitazone large and small doses of the intervention group and model of the 8 cases 9 cases and 10 cases of normal rats, 8 w after immunohistochemical and Western blot analysis of myocardial tissue expression of AQP1 . Results Rosiglitazone can reduce the release of myocardial enzymes, stable protein in myocardial tissue expression of AQP1, and the high dose group a significant effect of early diabetic rats has a protective effect. Conclusion Rosiglitazone can be stable AQP1 in early diabetic myocardial tissue expression, to a certain extent, ease the incidence of diabetic cardiomyopathy and development. [Keywords:] aquaporin 1; diabetic cardiomyopathy Studies suggest that type 2 diabetes early in excessive nutrients intake, especially long-term intake resulting in obesity will increase the inflammatory response, and systemic inflammatory cytokines and the heart with a local effect, in conjunction with the induction of diabetes, heart disease, diabetes occurs . In many pathological study of inflammation have shown the expression of AQPs (1), we have confirmed by previous experimental AQP1 in diabetic cardiomyopathy in rats than the normal tissue expression was decreased. Peroxisome proliferator-activated receptor (PPAR) as an important nuclear transcription factors, transcriptional regulation in the expression of many genes, play a regulating fatty acid and glucose metabolism, inhibit inflammatory reaction an important biological role (2). The further observation by PPAR agonist rosiglitazone on the diabetic rat heart in expression and regulation of the impact of AQP1 to discu