不同胎龄早产儿血脂生化指标的临床意义.docVIP

　　不同胎龄早产儿血脂生化指标的临床意义 作者：尹力扬，王红兵，徐丽，刘淑华，董雪萍，梁世磊，张大葵，李文斌 【摘要】 目的 通过测定不同胎龄早产儿血脂生化指标的变化，探讨其作为评价早产儿成熟度、营养状况及营养支持指标的临床意义。方法 早产儿组30例在入院后12 h内(出生后24 h)采集股静脉血2 ml，采血前2 h未喂养及输液。足月儿组30例在胎儿娩出、清理呼吸道后即刻采脐带血2 ml。测定血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、载脂蛋白B(ApoB)等生化指标。结果 早产儿组血清TC、TG、HDL-C、LDL-C、ApoA1、ApoB水平均低于足月儿组，2组之间差异具有统计学意义(Plt;0.01)。28～31 周的早产儿组血清TC、TG、HDL-C、LDL-C、ApoA1、ApoB水平均低于32～36 周的早产儿组，2组之间差异具有统计学意义(Plt;0.01)。结论 血脂生化指标可作为评价早产儿成熟度及营养状况的依据。检测血脂水平变化，对临床合理营养支持具有指导意义。 【关键词】 早产儿;血脂;成熟度;营养状况;营养支持 　　Abstract: Objective By measuring the biochemical changes in blood lipids in premature infants of different gestational age, to explore thEir clinical significance as biochemical indexes to evaluate the maturity, nutritional status and nutritional support in premature infants. Methods 30 premature infants admitted to hospital ature group. Blood collection of 2 ml ed from the femoral vEIn ission (24 hours after birth). 2 hours before blood collection, the premature infants received no transfusion or feeding. 30 neonates of term delivery underl from the umbilical cord immediately after delivery and airinations ical indicators including serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), lo TC, TG, HDL-C, LDL-C, ApoA1 and ApoB levels in the premature infant group ature neonate group. The results had statistical difference (Plt;0.01). Serum TC, TG, HDL-C, LDL-C, ApoA1 and ApoB levels in the premature infants of 28-31 ature infants ical indicators of blood lipid can be used as evidence of maturity and nutritional status in premature infants and the determination of the variations in the levels of blood lipids plays the role of a reasonable guide to clinical nutritional support. 　　Key ature infants; blood lipids; maturity; nutritional status; nutritional support 　　早产儿全身各系统发育未成熟，体质量低，营养差，且容易出现消化系统等许多并发症[1]。给予早喂养、部分或完全静脉营养等营养支持 治疗 ，是提高早产儿成活率的重要措施。本文旨在通过测定不同胎龄、体质量的早产儿血脂生化指标，并与正常足月新生儿血脂水平进行对照研究，探讨血脂生化指标对评价早产儿成熟度、