Staphylococcus carriers in the exchange of genes - SCCmec.docVIP

 PAGE \* MERGEFORMAT 21 Staphylococcus carriers in the exchange of genes - SCCmec [Abstract] MRSA in the world wide spread of hospital infection is one of the most common pathogenic bacteria. With the mobility of a new type of genetic element SCCmec carried mecA gene, and through the role of site-specific recombination into the chromosome of Staphylococcus, so that Staphylococcus aureus carrying the mecA gene, give rise to β -lactam antibiotics resistance drug effect. SCCmec is divided into 5 types and a variety of subtypes, different types of SCCmec its genetic components are also different, to adapt to different environments. I, II and III, SCCmec carrying multiple drug resistance gene, multi-drug resistant phenotype for the hospital environment; IV, and V-SCCmec is generally more portable, such MRSA can get a faster growth rate, suitable for the community environment . Internationally, different areas or different environments there are several types of MRSA epidemic can be divided into five major groups (CC5, CC8, CC22, CC30 and CC45). Different strains of MRSA is through access to different types of SCCmec, evolved through various channels. [Keywords:] MRSA; SCCmec; ccr complex; mec complex ABSTRACT MRSA has been spread internationally, and is the most common and prevalent pathogen in nosocomial infection. SCCmec, a novel mobile DNA element, is able to be integrated into the chromosome of S.aureus through site specific recombination, making S.aureus carry mecA mediating resistance to β -lactam antibiotics. There are 5 types and many subtypes of SCCmecs, and different types of SCCmecs adapt to different environment with their different genetic structure. Generally, type I, II and III SCCmecs carry many resistance genes, making them survive under antibiotic pressure in hospital; on the other hand, type IV and V SCCmecs are much smaller and have a faster growth rate, making them more inclined to exist in community. Internationally, prevalent MRSA can be di