Stem cell therapy of diabetes Recent.docVIP

 PAGE \* MERGEFORMAT 28 Stem cell therapy of diabetes Recent [Keywords:] diabetes islet stem cells, [Abstract] In this paper, this century a number of stem cells to treat diabetes research, including pancreatic islets in vivo Development, differentiation and markers, and the application of pancreatic ductal stem cells and embryonic stem cells induced to differentiate into directional Islet cell therapy for diabetes experiments are reviewed. With stem cell technology, continuous improvement, human Eventually be able to cure diabetes. Global Diabetes (diabetesmellitus, DM) patients is about 125 million (China also reached 40 million) Is expected by 2025 to reach 300 million [1], has become a serious hazard to human health, one of the major diseases, especially in Long illness caused by multi-system damage, and ultimately kidney failure. DM pathogenesis are complex and involve genetic, environmental, immune regulation, and chemical factors. Since the 1922 discovery of pancreatic Island Su-date, DM treatment with drugs and insulin injections based, at present, scholars have started to pay attention after islet transplantation Recovery in patients with metabolic disorders in vivo method, but the organization source scarcity has constrained the conduct of islet transplantation research, Therefore, to find a suitable study of islet graft has become a top priority. As the molecular, cellular and developmental biological Learn technological advances, an increase of stem cells induced to differentiate into the possibility of islet but because the technology is still in its Laboratory experimental stage, and the methods are not uniform, it is necessary to carry out summary of recent research, hoping Able to conduct research in this area has to help his colleagues. An islet in vivo formation, development, differentiation and identification of 1.1 fetal islet differentiation of embryonic islet differentiation of sub-four stages: (1) embr