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miR-146在湿性ARMD中抑制IL-6表达的研究
·实验研究·
miR-146 在湿性 ARMD中抑制 IL-6 表达的研究
郝摇 义1,孙摇 笑1,刘玉秋1,赵摇 允2,王摇 禹1
作者单位:1(113006)中国辽宁省抚顺市眼病医院;2(200031)
中国上海市,上海生命科学研究院
作者简介:郝义,主治医师,研究方向:眼科学基础。
通讯作者:王禹,硕士,主任医师,研究方向:眼科学基础. 163. com
收稿日期:2016-08-01摇 摇 修回日期:2017-03-14
Expression of IL-6 inhibited by miR-146
in the wet age - related
macular degeneration
Yi Hao1, Xiao Sun1, Yu - Qiu Liu1, Yun Zhao2,
Yu Wang1
1Fushun Ophthalmology Hospital, Fushun 113006, Liaoning
Province, China; 2Shanghai Institutes for Biological Sciences,
Chinese Academy of Sciences, Shanghai 200031, China
Correspondence to:Yu Wang. Fushun Ophthalmology Hospital,
Fushun 113006, Liaoning Province, China.@
163. com
Received:2016-08-01摇 摇 Accepted:2017-03-14
Abstract
誗AIM: To discuss the correlation between the expression
of miR-146 and aging retinal pigment epithelium (RPE),
and to study the relationship between miR - 146 and
expression of IL - 6 in RPE, especially in age - related
macular degeneration (ARMD) .
誗METHODS: The expressions of miR-146 and IL-6 were
examined in RPE in mice aged from 2mo to 24mo by qRT-
PCR. Then, the expressions of miR-146 and IL-6 in RPE
of wet ARMD patient were examined also. Finally, the
effect of overexpression of miR-146a in APRE-19 cell line
on expression of IL-6 was checked.
誗RESULTS: MiR- 146 was positive correlated with age,
and the expression of IL-6 had no change in aging RPE.
However, the expression of miR-146 decreased and IL-6
increased in RPE of ARMD. In cultured APRE - 19 cells,
overexpression of miR-146 inhibited the expression of
IL-6 induced by TNF-琢.
誗 CONCLUSION: Our results suggest that there is a
biological correlation among the development of ARMD,
expression of IL - 6 and miR - 146 in aging RPE. It also
suggests that, on the one hand, regulation between IL-6
and miR-146 may be important for the clinical treatment,
on the other hand, both IL - 6 and miR - 146 can be
potential molecular markers for diagnosing ARMD.
誗KEYWORDS:miR- 146; IL- 6; aging; wet age - related
macular
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