合适的转铁蛋白饱和度有助于血液透析患者血红蛋白持续达标.pdfVIP

中国血液净化2015年3 月第14卷第3期 Chin .T Blood Purif. March. 2015. Vo l. 3. No. 14 • 141 • ·临床研究· 合适的转铁蛋白饱和度有助于血液透析患者 血红蛋白持续达标 庞欣欣 张丽j吉 张枫朱宁崔专杨文领 毕淑红张爱华 范敏华 【摘要】目的 探讨持续性血液透析患者血红蛋白持续不达标的原因。 方法 收集2011 年1 月在 北医三院肾内科血液透析室透析的 113 例患者的临床资料，随访观察半年血红蛋白及生化检验指标至 2011 年7 月，男性62 例，女性51 例，平均年龄63 士 13 岁，每月检测血常规，每3 月检测 l 次血清铁，总铁综 合力并计算转铁蛋白饱和度，血清铁蛋白。血红蛋白目标值范围定为: 1 1O~125 g/L。根据随访开始半 年期间血红蛋白检测的每一个Hb 值分为2 组:持续达标组:观察期Hb 检测值均在目标范围，非持续达标 组。结果:在随访半年期间持续Hb 达标组19 例，各种非持续达标组94 例。持续达标组患者的血红蛋白 变异性(每个患者平均血红蛋白浓度均数的标准差)明显低于其他非持续达标组(3.9 士1. 4 比 6. 7 土 3. 8,P0. 01) ，转铁蛋白饱和度明显高于其他非持续达标组(32. 8% ::t 15.8% 比 24.4%士7. 9% ,t=-2.209,P = 0.035) 。 结论合理的转铁蛋臼饱和度(平均值32.8%) 有助于血液透析患者维持血红蛋白持续达标。 【关键词】血液透析，转铁蛋白饱和度，血红蛋白变异性 中图分类号:R318.6 文献标识码:A doi :10. 3969/j. issn.1671-4091. 2015. 03. 005 Appropriate 位ansferrÏn saturation is beneficial for continuous achievement of targeted hemoglobin level in he- modialysis patients PANG Xin- xin, ZHANG Li气jie， ZHANG Fe咯 ZHUNin多 CUI Zhuan, YANG 陆~­ /ing, BI Shu-hong, ZHANG Ai-hua， 元4NMin-hua DepartJηent ofNephrology, Peking University Third Hos- pita1, B吵略 100191 China COITe.句pondingau的or: Zhang Ai-hua, Emai1: zhangaihua0982~罗 Abstract Objective To study the relationship between 位ansferrin saturation and the achievement of tar- geted hemoglobin level in hemodialysis patients. Methods One hundred thirteen hemodialysis patients (mean age63土13 years; 62 males and 51 females) were treated in the dialysis center in Jan. 2011 , and were followed up until July 201 1. Their hemoglobin was measured every month , and their serum iron, ferrtin and total iron- binding capacity were examined every three months.ηle targeted hemoglobin level was set at l lO~ 125 g/L. Patients were classified based on their hemoglobin level in the 6 months into two groups: continuous achieve- ment of targeted hemoglobin