Comparative study of the side effect profiles of oral misoprostol and parenteral oxytocin used in prevention of postpartum haemorrhage in Maiduguri Nigeria.docVIP

Open Journal of Obstetrics and Gynecology, 2013, 3, 208-211 OJOG /10.4236/ojog.2013.31A038 Published Online February 2013 (/journal/ojog/) Comparative study of the side effect profiles of oral misoprostol and parenteral oxytocin used in prevention of postpartum haemorrhage in Maiduguri Nigeria* Sadiq G. Uthman , Mairiga A. Garba , Ado G. Danazumi , Mairo U. Mandara , 1# 2 2 3 4 Nwaosu H. Sylvester 1 2 3 Department of Ethno-Pharmacy and Drug Development, Faculty of Pharmacy, University of Maiduguri, Maiduguri, Nigeria Department of Obstetrics and Gynaecology, University of Maiduguri, Maiduguri, Nigeria Population and Reproductive Health Research Initiative of Department of Obstetrics and Gynaecology, Ahmadu Bello University Teaching Hopspital, Zaria, Nigeria Department of Maths and Statistics, Faculty of Science, University of Maiduguri, Maiduguri, Nigeria 4 Email: garbaus2000@yahoo.co.uk # Received 29 September 2012; revised 30 October 2012; accepted 8 November 2012 ABSTRACT 1. INTRODUCTION The following work compared adverse effects profile and patients’ acceptability of intra-venous oxytocin 10 iu and oral misoprostol 600 ug used in the preven- tion of postpartum hemorrhage in the third stage of labour. A total of 1865 pregnant women who have re- ceived either oxytocin injection or oral misoprostol in third stage of labour as prophylaxis for postpartum haemorrhage, were enrolled within three health care facilities in Maiduguri, Nigeria. Each patient was ob- served at parturition and for 24 h after during which oral interviews were conducted and clinical notes stu- died. The oxytocin medication group exhibited higher abdominal pains (7.1% versus 0.0%; p 0.001) and headache (1.9% versus 0.1%; p 0.001), while the misoprostol group showed higher shivering (33.9%