EFFECT OF SIMVASTATIN TREATMENT ON BONE MINERAL DENSITY IN HYPERCHOLESTEROLEMIC POSTMENOPAUSAL WOMEN.docVIP

EFFECTOFSIMVASTATINTREATMENTONBONEMINERALDENSITY INHYPERCHOLESTEROLEMICPOSTMENOPAUSALWOMEN DimitrijeJankovic,TodorkaSavic,IrenaJankovic,DejanSpiroski andBojanPesic1 1 2 1 1 Statinsareabletoreducecardiovascularmorbidityandmortalitymainlythroughtheir hypocholesterolemiceffect.Beyondtheinhibitionofcholesterolsynthesis,theidentificationof pleiotropicmechanismshas motivated many studies to evaluatetheeffectsof statinuseonbone mineraldensity(BMD)modification. Theaimofourstudywastoevaluatewhethersimvastatintreatment(20mg/d)could modify BMD in hypercholesterolemic women (n=28) after one-year treatment as compared withacontrolgrouptreatedonlywithadiet(n=11).Theexclusioncriteriawascurrentorprevi- oustherapywithstatins,bisphosphonatesand/orestrogens.Thefollowingparameterswerede- termined at the beginning and after one year, and those are: total cholesterol, triglycerides, HDL-CandLDL-C(Friedewaldequation).TheBMDwasmeasuredatthelumbarspinebydual energyx-rayabsorpiometry(DEXA). Inthesimvastatintreatedgroup,BMDshowedaninsignificant2,812%increaseafter12 months, respectively (0,965+0,111 v 0,992+0,110, P0,05). The group treated only with hypolipidic diet demonstrated a 3,45% decrease in BMD (respectively, 1,042+0,181 v 1.006+0,182;P0,05)after12months.Nevertheless,thecomparisonofaverageBMDchanges between the two examined groups during one year showed a significant value diference (-0,027+0,037v0,036+0,036;P0,0006). Aspartlysuggestedbyretrospectiveorobservationaldata,thislongitudinalstudyindi- catesthatsimvastatintreatment achievesabeneficialeffectonBMD.ActaMedicaMedianae 2005;44(2):61?65. Keywords:simvastatin,bonemineraldensity,hypercholesterolemia,postmenopausal women Instituteforprevention,treatmentandrehabilitationofrheumaticand ofbonehealthduetotheinterferencewithbonemetab- olism through various mechanisms: the reduction of signalproteinsregulatingosteoclastactivity(3)andthe increasedexpressionofbonemorphogeneticprotein-2 geneintheratbonetissue(4).Thesemechanismscould re