甲苯磺酸索拉非尼治疗进展期肝细胞癌常见不良反应的护理观察.pdfVIP

中华护理杂志 2012 年 1 月第47 卷第 1 期 Chin J Nurs , January 2012 , Vol 47 , No.l • 45 • 甲苯磺酸索拉非尼治疗进展期肝细胞癌常见不良反应的护理观察 安林静徐漠研张丽娜李因茵石艳丽李慧杨永乎 【摘要1 目的 观察甲苯磺酸索拉非尼治疗进展期肝细胞癌(HCC) 的不良反应。方法 采用美国国立癌症研究所常见毒性分 级标准观察不良反应发生情况.并对出现的不良反应采取针对性的护理措施。结果 最常见的不良反应为手足综合征 (65.5lJ串) ，最平出现的不良反应为腹泻;常见3级不良反应为手足综合征(15.5%) 、肝损害(8.2%) 、腹泻 (4.5%)、高血压 (3.6%)和 出血(2.7%)0 4级不良反应有肝损伤(6.4%扒出血(4.5%) 和腹泻(1.8%) ;采取针对性的护理措施可缓解药物不良反应。结论 对110例用药后产生的不良反应进行分级比较，并根据轻重程度给予不同的护理，可提高治疗效果。 [关键词1 药物疗法; 肝肿瘤; 护理 Observation of adv.erse drug reactions of sorafenib tosylate in patients with advanced hepatoceUular carcinoma/AN Li叫i吨，XU MO-yan ,ZHANG Li-I阁，LI Yin-泸n， SHI Yan- Ii, LI H时，YANG Yong-ping (Abstract] Objective To observe the adverse drug reactions of sorafenib tosylate in patients with advanced hepatocellular carcinoma. Methods The adverse drug reactions of sorafenib tosylate in patients with advanced hepatocellular carcinoma were identified ac吧。rding to U.S. National Cancer Institute Common Toxicity Criteria.τnen , targeted measures were taken to treat 由e adverse. drug 陀actions. Results The most common adverse drug reaction wωhand-foot syndrome (65.5 pe陀ent ). Diarrhea appeared firstly. The common grade-II1 adverse drug reactions were hand-foot syndrome (l5.5 percent) ,liver damage(8.2 percent) , diar由ea(4.5 pe眈ent) ,hypertension(3.6 percent) and bleeding(2.7 percent). 四le common grade-IV adverse drug reactions were liver damage(6.4 percent) ,bleeding(4 .5 percent) and diarrhea( 1.8 pereent). Proper targeted me田ures could alleviate the drug toxicity. Conclusion Grading of the adverse drug reactions and taking proper measures according to the severity of adverse drug reactions can improve 由e treatment effectiveness. (Key words] Drug Therapy; Liver Neoplasms; Nursing Care 肝癌的发病机制十分复杂，其发生、发展和转移与多种基 报告如下。 因的突变、细胞信号传导通路相血管内皮生长因子受体-2 1 临床资料 (VEGFR-2) 、血管内皮宅K肘子受体-3 (