MADLforCadmium(Oral)-OEHHA.pdfVIP

Proposition 65 Maximum Allowable Daily Level (MADL) for Reproductive Toxicity for Cadmium (Oral Route) May 2001 Office of Environmental Health Hazard Assessment (OEHHA) Reproductive and Cancer Hazard Assessment Section Summary The maximum allowable daily level (MADL) for cadmium exposure by the oral route is 4.1 µg/day. This value was derived as described below, based on a developmental toxicity study in mice conducted by Ali et al. (1986). Background This report describes the derivation of a maximum allowable daily level (MADL) for cadmium (CAS # 71-43-28), a chemical listed under Proposition 65 as known to the State to cause reproductive toxicity, effective May 1, 1997. Exposure at a level 1,000 times greater than the MADL is expected to have no observable effect. Procedures for the development of Proposition 65 MADLs are provided in regulation (Title 22, California Code of Regulations [22 CCR], Sections 12801 and 12803). The Proposition 65 listing of cadmium was based on a finding by the Developmental and Reproductive Toxicant (DART) Identification Committee, the Proposition 65 state’s qualified experts for reproductive toxicity, that the chemical had been clearly shown by scientifically valid testing according to generally accepted principles to cause developmental and male reproductive toxicity. As part of its deliberations, the Committee reviewed the document “Evidence on Developmental and Reproductive Toxicity of Cadmium” (OEHHA, 1996), a comprehensive review of the scientific literature on the adverse reproductive effects of cadmium. This review serves as the primary reference for MADL development. As defined in regulations, MADLs are derived from No Observable Effect Levels (NOELs) or Lowest Observable Effect Levels (LOELs) (22 CCR Sections 12801 and 12803). The values discussed below are the highest exposure level at which