GLUT4在胰岛素调控葡萄糖转运中作用.PDFVIP

· 285 · 生命的化学, 2014, 34(2): 285-290 唐海双, 等. GLUT4w在ww胰.l岛ife素.ac调.c控n 葡萄糖转运中作用 doi: 10.13488/j .smhx GLUT4 在胰岛素调控葡萄糖转运中作用 1 1 2 2 * 唐海双 ，王清松 ，焦炳华 ，杨生生 (1 4 200433 2 200433) 第二军医大学临床医学 队，上海 ；第二军医大学基础部生物化学与分子生物学教研室，上海 摘要：机体的血糖平衡调节主要依赖于胰岛素，其中一个重要的机制是胰岛素通过调控GLUT4的囊泡 运转来调节脂肪细胞和肌细胞对葡萄糖的摄取。由胰岛素受体介导的一系列磷酸化过程能调节一些关 GLUT4 GTP 键的 转运相关蛋白质的活性，这些蛋白质包括小 酶、拴系复合体和囊泡融合体。而这些蛋 白质又反过来通过内膜系统调节GLUT4储存囊泡的生成、滞留，并调控这些囊泡的靶向出胞方式。了 解这些过程有助于解释2型糖尿病中胰岛素耐受的机制，并可能为糖尿病提供新的靶向治疗方法。 关键词：胰岛素；葡萄糖；GLUT4 The role of GLUT4 in regulation of glucose transport by insulin 1 1 2 2 * TANG Haishuang , WANG Qingsong , JIAO Binghua , YANG Shengsheng 1 ( Four Team of Clinic Medicine Department, the Second Military Medical University, Shanghai 200433, China; 2Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences, the Second Military Medical University, Shanghai 200433, China) Abstract: The regulation of plasma glucose levels mainly depends on insulin, and one of the key mechanisms is that insulin increases glucose uptake into fat and muscle cells through the regulated trafficking of vesicles that contain glucose transporter type 4 (GLUT4). The insulin signalling has revealed that phosphorylation events initiated by the insulin receptor regulate key GLUT4 trafficking proteins, including small GTPases, tethering complexes and the vesicle fusion machinery. These proteins, in turn, c