Anthropometric Measures and Physical Activity and the Risk of Lung Cancer in Never-Smokers A Prospective Cohort Study.docVIP

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Anthropometric Measures and Physical Activity and the Risk of Lung Cancer in Never-Smokers A Prospective Cohort Study.doc

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Anthropometric Measures and Physical Activity and the Risk of Lung Cancer in Never-Smokers A Prospective Cohort Study

AnthropometricMeasuresandPhysicalActivityandthe RiskofLungCancerinNever-Smokers:AProspective CohortStudy TramKimLam1*,SteveC.Moore2,LouiseA.Brinton3,LlewellynSmith4,AlbertR.Hollenbeck5, GretchenL.Gierach3,NealD.Freedman2 1GeneticEpidemiologyBranch,DivisionofCancerEpidemiologyandGenetics,NationalCancerInstitute,NationalInstitutesofHealth,Rockville,Maryland,UnitedStates ofAmerica,2NutritionalEpidemiologyBranch,DivisionofCancerEpidemiologyandGenetics,NationalCancerInstitute,NationalInstitutesofHealth,Rockville,Maryland, UnitedStatesofAmerica,3HormonalandReproductiveEpidemiologyBranch,DivisionofCancerEpidemiologyandGenetics,NationalCancerInstitute,NationalInstitutes of Health, Rockville, Maryland, United States of America, 4Williams College, Williamstown, Massachusetts, United States of America, 5Organizational and Tracking ResearchDepartment,AARP,Washington,DistrictofColumbia,UnitedStatesofAmerica Abstract Worldwide,lungcancerinnever-smokersisrankedtheseventhmostcommoncauseofcancerdeath;however,theetiology oflungcancerinnever-smokersisunclear.Weinvestigatedassociationsforbodymassindex(BMI)atvariousages,waist circumference,hipcircumference,andphysicalactivitywithlungcancerin158,415never-smokersoftheNIH-AARPDietand Health Study. Multivariable hazard ratios (HR) and 95% confidence intervals (CI) were estimated from Cox proportional hazardsmodels.Over11yearsoffollow-up,532lungcancercasesoccurred.Theriskestimateforobese(BMI$30kg/m2) participants at baseline was 1.21 (95%CI=0.95–1.53) relative to those with a normal BMI between 18.5#BMI,25.0. Overweight (25.0#BMI,30.0) at age 18 (HRoverweight-vs-normal =1.51;95%CI=1.01–2.26) and time spent sitting (HR$ 3 hrs-vs- ,3 hrs=1.32;95%CI=1.00–1.73)waseachassociatedwithlungcancerafteradjustmentforbaselineBMI,aswaswaist(HRQ4- vs-Q1=1.75;95%CI=1.09–2.79)andhipcircumference(HRQ4-vs-Q1=0.62;95%CI=0.39–0.99),aftermutualadjustmentforeach otherandbaselineBMI.Noassociationswereobservedforvigorousactivityortelevisionwatching. Insumma