Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice.docVIP

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Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice.doc

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Anti-Obesity Effect of Lactobacillus gasseri BNR17 in High-Sucrose Diet-Induced Obese Mice

Anti-ObesityEffectofLactobacillusgasseriBNR17in High-SucroseDiet-InducedObeseMice Ji-HeeKang*,Sung-IlYun,Mi-HeePark,Jun-HongPark,So-YoungJeong,Han-OhPark RDcenter,BioneerCorporation,Daejeon,RepublicofKorea Abstract Previously, we reported that Lactobacillus gasseri BNR17 (BNR17), a probiotic strain isolated from human breast milk, inhibited increases in body weight and adipocyte tissue weight in high-sucrose diet-fed Sprague-Dawley (SD) rats and reducedglucoselevelsintype2diabetesmice.Inthecurrentstudy,weconductedfurtherexperimentstoextendthese observations and elucidate the mechanism involved. C57BL/6J mice received a normal diet, high-sucrose diet or high- sucrosedietcontainingL.gasseriBNR17(109or1010CFU)for10weeks.TheadministrationofL.gasseriBNR17significantly reducedthebodyweightandwhiteadiposetissueweightregardlessofthedoseadministered.InBNR17-fedgroups,mRNA levels of fatty acid oxidation-related genes (ACO, CPT1, PPARa, PPARd) were significantly higher and those of fatty acid synthesis-related genes(SREBP-1c,ACC)werelower comparedtothehigh-sucrose-diet group.TheexpressionofGLUT4, mainglucosetransporter-4,waselevatedinBNR17-fedgroups.L.gasseriBNR17alsoreducedthelevelsofleptinandinsulin inserum.Theseresultssuggestthattheanti-obesityactionsofL.gasseriBNR17canbeattributedtoelevatedexpressionof fattyacidoxidation-relatedgenesandreducedlevelsofleptin.Additionally,datasuggestedtheanti-diabetesactivityofL. gasseriBNR17maybetodueelevatedGLUT4andreducedinsulinlevels. Citation:KangJ-H,YunS-I,ParkM-H,ParkJ-H,JeongS-Y,etal.(2013)Anti-ObesityEffectofLactobacillusgasseriBNR17inHigh-SucroseDiet-InducedObese Mice.PLoSONE8(1):e54617.doi:10.1371/journal.pone.0054617 Editor:KathrinMaedler,UniversityofBremen,Germany ReceivedJuly8,2012;AcceptedDecember13,2012;PublishedJanuary30,2013 Copyright: ? 2013 Kang etal. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanym