Anti-diabetic and antioxidant effects of virgin coconut oil in alloxan induced diabetic male Sprague Dawley rats.docVIP

Vol.3, No.4, 221-226 (2013) Journal of Diabetes Mellitus /10.4236/jdm.2013.34034 Anti-diabetic and antioxidant effects of virgin coconut oil in alloxan induced diabetic male Sprague Dawley rats Bolanle Iranloye , Gabriel Oludare , Makinde Olubiyi 1* 1 1,2 1 * 2 Department of Physiology, College of Medicine, University of Lagos, Lagos, Nigeria; Corresponding Author: bolasunkanmi45@ Department of Physiology, Kogi State University, Ayangba, Nigeria Received 25 September 2013; revised 20 October 2013; accepted 28 October 2013 Copyright ? 2013 Bolanle Iranloye et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT 0.05 in DT7.5 (2.634 ± 0.04) and DT10 rats (2.258 ± 0.32) when compared to DUT rats (1.366 ± 0.05) while MDA significantly reduced p 0.05 in DT7.5 (49.16 ± 0.51) and DT10 (33.64 ± 0.42) rats when compared to DUT rats (99.93 ± 4.79). This study revealed that VCO has a hypoglycemic action, enhances insulin secretion and also ameliorates oxidative stress induced in type I (alloxan-in- duced diabetic) male rats. Oxidative stress has been discovered to be in- volved in the progression of diabetes mellitus. The antioxidant properties of virgin coconut oil (VCO) among other functions might have a be- neficial effect in ameliorating the disease. This study was aimed to determine the glycemic and antioxidant effects of VCO in alloxan induced diabetic rats. 24 male Sprague-Dawley rats were divided into 4 groups as follows: control (C), dia- betes untreated (DUT), diabetes treated with 7.5 ml/kg VCO (DT7.5) and diabetes treated with 10 ml/kg VCO (DT10). Alloxan (100 mg/kg b.w I.P) was used to induce diabetes and VCO was ad- ministered orally once da