Antibiotic Stewardship Ward Rounds and a Dedicated Prescription Chart Reduce Antibiotic Consumption and Pharmacy Costs without Affecting Inpatient Mortality or Re-Admission Rates.docVIP

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Antibiotic Stewardship Ward Rounds and a Dedicated Prescription Chart Reduce Antibiotic Consumption and Pharmacy Costs without Affecting Inpatient Mortality or Re-Admission Rates.doc

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Antibiotic Stewardship Ward Rounds and a Dedicated Prescription Chart Reduce Antibiotic Consumption and Pharmacy Costs without Affecting Inpatient Mortality or Re-Admission Rates

Antibiotic Stewardship Ward Rounds and a Dedicated Prescription Chart Reduce Antibiotic Consumption and Pharmacy Costs without Affecting Inpatient Mortality or Re-Admission Rates Tom H. Boyles , Naazneen Rawoot , Peter Raubenheimer 1 , Andrew Whitelaw , Vanishree Naicker , Sipho Dlamini 2,3,4 , Colleen Bamford , Irena Lusakiewicz , Marc Mendelson 1* 2,3 , Mischka Moodley 2,3 , Kim Bonorchis , Vida 2,3 Morris 5 6 6 6 , John Black 1 1 , David Stead , Maia Lesosky 7 8 1 1 Division of Infectious Diseases and HIV Medicine, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa, 2 National Health Laboratory Service, Groote Schuur Hospital, Cape Town, South Africa, 3 Division of Medical Microbiology, University of Cape Town, Cape Town, South Africa, 4 Division of Medical Microbiology, University of Stellenbosch, Cape Town, South Africa, 5 Quality Assurance, Groote Schuur Hospital, Cape Town, South Africa, 6 Pharmacy, Groote Schuur Hospital, Cape Town, South Africa, 7 Department of General Medicine, University of Cape Town, Cape Town, South Africa, 8 Division of General Internal Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa Abstract Background: Antibiotic consumption is a major driver of bacterial resistance. To address the increasing burden of multi-drug resistant bacterial infections, antibiotic stewardship programmes are promoted worldwide to rationalize antibiotic prescribing and conserve remaining antibiotics. Few studies have been reported from developing countries and none from Africa that report on an intervention based approach with outcomes that include morbidity and mortality. Methods: An antibiotic prescription chart and weekly antibiotic stewardship ward round was introduced into two medical wards of an academic teaching hospital in South Africa between January-December 2012. Electronic pharmacy record