Association of monoctye expression of Toll-like receptor 4 and its related cytokines with coronary luminal stenosis.docVIP

Advances in Bioscience and Biotechnology, 2013, 4, 19-25 ABB /10.4236/abb.2013.47A1004 Published Online July 2013 (/journal/abb/) Association of monoctye expression of Toll-like receptor 4 and its related cytokines with coronary luminal stenosis Bahador Bagheri , Bahram Sohrabi , Aliakbar Movassaghpur , Simin Mashayekhi , Afagh Garjani , 1 2 3 4 5 2 2 1* Mehriar Shokri , Mohammad Noori , Alireza Garjani 1 2 3 4 5 Department of Pharmacology, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran Shahid Madani Heart Hospital, Tabriz University of Medical Sciences, Tabriz, Iran Hematology Research Centre, Tabriz University of Medical Sciences, Tabriz, Iran Departmentof Clinical Pharmacy, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Email: * garjania@tbzmed.ac.ir, garjania2002@ Received 18 April 2013; revised 20 May 2013; accepted 30 May 2013 Copyright ? 2013 Bahador Bagheri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Keywords: Atherosclerosis; Cytokines; Inflammation; hTLR4 Toll-like receptors are well-defined barriers in innate immunity. Among them hTLR4 on the surface of monocytes, plays a critical role in the formation of atherosclerotic plaques, plaque instability and arte- rial remodeling through production of inflammatory cytokines. This study was designed to examine the association of hTLR4 monocyte expression and re- sponse