Association of SMAD7 rs12953717 Polymorphism with Cancer A Meta-Analysis.docVIP

AssociationofSMAD7rolymorphismwith Cancer:AMeta-Analysis HongtuanZhang1,HuiMa2,YongXu1*,LiangLi3 1DepartmentofUrology,SecondAffiliatedHospitalofTianjinMedicalUniversity,TianjinKeyInstituteofUrology,Tianjin,China,2DepartmentofEpidemiology,Schoolof PublicHealth,TianjinMedicalUniversity,Tianjin,China,3LaboratoryofPopulationandQuantitativeGenetics,SchoolofLifeSciences,TianjinMedicalUniversity,Tianjin, China Abstract Background:AccumulatingevidencehassuggestedthatMothersagainstdecapentaplegichomolog7(SMAD7)rpolymorphism might be related to cancer risk. However, epidemiologic findings have been inconsistent. We therefore performedameta-analysistoclarifytheassociationbetweentheSMAD7rolymorphismandcancerrisk. Methods:AcomprehensivesearchwasconductedtoidentifyalleligiblestudiesofSMAD7rolymorphismand cancerrisk.Weusedoddsratios(ORs)toassessthestrengthoftheassociation,and95%confidenceintervals(CIs)togivea senseoftheprecisionoftheestimate.Heterogeneity,publicationbias,andsensitivityanalysiswerealsoexplored. Results:Atotalof14case-controlstudies,including16928casesand14781controls,wereincludedinthepresentmeta- analysis. The overall results showed that the variant genotypes were associated with a significantly increased risk of all cancer types (homozygote comparison, OR=1.23, 95%CI=1.10–1.38, P,0.01; heterozygote comparison, OR=1.12, 95%CI=1.02–1.22, P=0.02; recessive model, OR=1.17, 95%CI=1.07–1.29, P,0.01; dominant model, OR=1.15, 95%CI=1.06–1.25, P,0.01;allelic model,OR=1.12,95%CI=1.06–1.18, P,0.01).Further sensitivity analysisconfirmed the significantassociation.Inthesubgroupanalysisbyethnicity,SMAD7rolymorphismwassignificantlyassociated withcancerriskinbothCaucasiansandAsians.Inthesubgroupanalysisbycancertypes,SMAD7rolymorphism wassignificantlyassociatedwithcolorectalcancer. Conclusions:Ourinvestigationsdemonstratethatrolymorphismisassociatedwiththesusceptibilityofcancer. Large-scaleandwell-de