Association of Vitamin D Receptor BsmI Gene Polymorphism with Risk of Tuberculosis A Meta-Analysis of 15 Studies.docVIP

AssociationofVitaminDReceptorBsmIGene PolymorphismwithRiskofTuberculosis:AMeta-Analysis of15Studies Yu-jiaoWu1,2.,XinYang3,4.,Xiao-xiaoWang5,Man-TangQiu3,4,Yi-zhongYou6,Zhi-xinZhang7 ,Shan- meiZhu1,LinXu3,4*,Feng-leiTang1* 1Department of Pharmacy, Changzhou Third People’s Hospital, Changzhou, China, 2College of Pharmacy, Soochow University, Suzhou, China, 3The Fourth Clinical CollegeofNanjingMedicalUniversity,Nanjing,China,4DepartmentofThoracicSurgery,NanjingMedicalUniversityAffiliatedCancerHospitalCancerInstituteofJiangsu Province, Nanjing, China, 5Department of Bio-statistics, Georgia Health Science University, Augusta, Georgia, United States of America, 6Department of Pharmacy, ChangzhouFirstPeople’sHospital,Changzhou,China,7DepartmentofPulmonaryTuberculosis,ChangzhouThirdPeople’sHospital,Changzhou,China Abstract Background: Genetic variations in vitamin D receptor (VDR) may contribute to tuberculosis (TB) risk. Many studies have investigatedtheassociationbetweenVDRBsmIgenepolymorphismandTBrisk,butyieldedinconclusiveresults. Methodology/Principal Findings: We performed a comprehensive meta-analysis of 15 publications with a total of 2309 casesand3568controls.WeassessedthestrengthoftheassociationbetweenVDRBsmIgenepolymorphismandTBrisk and performed sub-group analyses by ethnicity, sample size and Hardy–Weinberg equilibrium (HWE). We found a statisticallysignificantcorrelationbetweenVDRBsmIgenepolymorphismanddecreasedTBriskinfourcomparisonmodels: allele model (b vs. B: OR=0.78, 95% CI=0.67, 0.89; Pheterogeneity=0.004), homozygote model (bb vs. BB: OR=0.61, 95% CI=0.43,0.87;Pheterogeneity=0.001),recessivemodel(bbvs.Bb+BB:OR=0.70,95%CI=0.56,0.88;Pheterogeneity=0.005)and dominant model (bb+Bb vs. BB: OR=0.77, 95% CI=0.61, 0.97; Pheterogeneity=0.010), especially in studies based on Asian population. Sub-group analyses also revealed that there was a statistically decreased TB risk in ‘‘small’’ studies (,500 participants) and studies with PHWE.0.5. Meta-regression and