B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response.docVIP

下载本文档

3
0
约6.66万字
约 14页
2017-05-07 发布于上海
举报
版权申诉

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response.doc

1、本文档共14页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response

BCellsRegulateNeutrophiliaduringMycobacterium tuberculosisInfectionandBCGVaccinationby ModulatingtheInterleukin-17Response LeeKozakiewicz1.,YongChen1.,JiayongXu1,YanhuaWang2,KyriDunussi-Joannopoulos3,QinglinOu4, JoanneL.Flynn5,StevenA.Porcelli1,6,WilliamR.Jacobs,Jr.1,7,JohnChan1,6 * 1Department of Microbiology and Immunology, Albert Einstein College of Medicine, the Bronx, New York, New York, United States of America, 2Department of Pathology,AlbertEinsteinCollegeofMedicine,theBronx,NewYork,NewYork,UnitedStatesofAmerica,3ImmunologyandAutoimmunity,BiotherapeuticResearch, Pfizer,Cambridge,Massachusetts,UnitedStatesofAmerica,4DepartmentofImmunologyandAntibodyEngineering,Genentech,SanFrancisco,California,UnitedStates of America, 5Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, 6DepartmentofMedicine,AlbertEinsteinCollegeofMedicine,Bronx,NewYork,UnitedStatesofAmerica,7HowardHughesMedicalInstitute,AlbertEinsteinCollegeof Medicine,theBronx,NewYork,NewYork,UnitedStatesofAmerica Abstract WehavepreviouslydemonstratedthatBcellscanshapetheimmuneresponsetoMycobacteriumtuberculosis,includingthe level ofneutrophil infiltrationand granulomatousinflammation at thesite of infection. Thepresent study examined the mechanismsbywhichBcellsregulatethehostneutrophilicresponseuponexposuretomycobacteriaandhowneutrophilia may influence vaccine efficacy. To address these questions, a murine aerosol infection tuberculosis (TB) model and an intradermal(ID)earBCGimmunizationmousemodel,involvingboththemMTstrainandBcell-depletedC57BL/6mice,were used.IL(interleukin)-17neutralizationandneutrophildepletionexperimentsusingthesesystemsprovideevidencethatB cellscanregulateneutrophiliabymodulatingtheIL-17responseduringM.tuberculosisinfectionandBCGimmunization. ExuberantneutrophiliaatthesiteofimmunizationinBcell-deficientmiceadverselyaffectsdendriticcell(DC)migrationto thedraininglymphnodesandattenuatesthed