Basolateral Amygdala Lesion Inhibits the Development of Pain Chronicity in Neuropathic Pain Rats.docVIP

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Basolateral Amygdala Lesion Inhibits the Development of Pain Chronicity in Neuropathic Pain Rats.doc

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Basolateral Amygdala Lesion Inhibits the Development of Pain Chronicity in Neuropathic Pain Rats

BasolateralAmygdalaLesionInhibitstheDevelopment ofPainChronicityinNeuropathicPainRats ZhengLi1,3.,JingWang2.,LinChen1,3,MengZhang1,3,YouWan1,3 * 1NeuroscienceResearchInstitute,PekingUniversity,Beijing,P.R.China,2NationalKeyLaboratoryofCognitiveNeuroscienceandLearning,SchoolofBrainandCognitive Sciences,BeijingNormalUniversity,Beijing,P.R.China,3KeyLaboratoryforNeuroscience,MinistryofEducation/NationalHealthandFamilyPlanningCommission,Peking University,Beijing,P.R.China Abstract Background:Chronicityofpainisoneofthemostinterestingquestionsinchronicpainstudy.Clinicalandexperimental datasuggestthat supraspinal areasresponsiblefor negativeemotions suchas depressionandanxiety contribute tothe chronicityofpain.Theamygdalaissuspectedtobeapotentialstructureforthepainchronicityduetoitscriticalrolein processingnegativeemotionsandpaininformation. Objective: This study aimed to investigate whether amygdala or its subregions, the basolateral amygdala (BLA) and the centralmedialamygdala(CeA),contributestothepainchronicityinthesparednerveinjury(SNI)-inducedneuropathicpain modelofrats. Methodology/PrincipalFindings:(1)BeforetheestablishmentoftheSNI-inducedneuropathicpainmodelofrats,lesionof theamygdaloidcomplexwithstereotaxicinjectionofibotenicacid(IBO)alleviatedmechanicalallodyniasignificantlyatdays 7 and 14, even no mechanical allodynia at day 28 after SNI; Lesion of the BLA, but not the CeA had similar effects; (2) however,7daysafterSNIwhentheneuropathicpainmodelwasestablished,lesionoftheamygdalacomplexortheBLAor theCeA,mechanicalallodyniawasnotaffected. Conclusion: These results suggest that BLA activities in the early stage after nerve injury might be crucial to the developmentofpainchronicity,andamygdala-relatednegativeemotionsandpain-relatedmemoriescouldpromotepain chronicity. Citation:LiZ,WangJ,ChenL,ZhangM,WanY(2013)BasolateralAmygdalaLesionInhibitstheDevelopmentofPainChronicityinNeuropathicPainRats.PLoS ONE8(8):e70921.doi:10.1371/journal.pone.0070921 Editor:TheodoreJohnP