Being an Only or Last-Born Child Increases Later Risk of Obesity.docVIP

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Being an Only or Last-Born Child Increases Later Risk of Obesity.doc

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Being an Only or Last-Born Child Increases Later Risk of Obesity

BeinganOnlyorLast-BornChildIncreasesLaterRiskof Obesity LineK.Haugaard1.,TeresaA.Ajslev1*.,EstherZimmermann1,LarsAngquist¨ 1,ThorkildI.A.S?rensen1,2 1Institute of Preventive Medicine, Frederiksberg and Bispebjerg University Hospitals, Frederiksberg, Denmark, 2Novo Nordisk Foundation Center for Basic Metabolic Research,FacultyofHealthandMedicalSciences,UniversityofCopenhagen,Copenhagen,Denmark Abstract Background:Studieshavesuggestedthatnumberofsiblingsandbirthorderisassociatedwithobesity.However,studies combiningtheseexposuresareneeded.Thisstudyaimedatinvestigatingobesityinchildrenandyoungadultsinregardto differentcombinationsoffamilysizeandbirthorder. Methods:Twocohortsselectedfromthegeneralpopulationwereinvestigated:TheCopenhagenSchoolHealthRecords Register(CSHRR)andaDraftBoard(DB)samplewithmeasuredheightsandweightsinchildhood(age13years)andyoung adulthood(age19years),respectively.Informationonbirthorder,numberofsiblings,andrelevantcovariateswereavailable on29327children,aswellason323obeseyoungmenand575randomlyselectedcontrolsofyoungmenrepresenting approximately58000.Therelationbetweennumberofsiblingsandbirthorder,respectively,andhavingaBodyMassIndex (BMI)z-scoreaboveorequaltothe95thpercentileinchildhoodorhavingaBMIofatleast31.00kg/m2inyoungadulthood wasanalysedusinglogisticregressionanalysesadjustedforrelevantconfounders. Results:Onlychildrenhadsignificantlyhigheroddsofobesitybothinchildhoodandinyoungadulthoodcomparedwith children with siblings, odds ratio (OR)=1.44 (95% Confidence Interval (CI): 1.26–1.66) and OR=1.76 (95% CI: 1.18–2.61), respectively.Noassociationbetweenfirst-bornstatusandobesitywasfound.TheORoflast-bornchildrenbeingobesewas alsosignificantlyincreasedinchildhood,e.g.OR=1.93(95%CI:1.0923.43)ofobesityiflast-borninafamilyoffourchildren. This was not found in young adulthood. Additionally, higher spacing to previous sibling (average 1872 vs. 1303 days; p=0.026infourchildrenfamilies)wasobservedinobeselast-borncomparedtonon-obeselast-