Circulation of Dferent Lineages of Dengue Virus 2, Genotype AmericanAsian in Brazil Dynamics and Molecular and Phylogenetic Characterization.docVIP
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Circulation of Dferent Lineages of Dengue Virus 2, Genotype AmericanAsian in Brazil Dynamics and Molecular and Phylogenetic Characterization
CirculationofDifferentLineagesofDengueVirus2,
GenotypeAmerican/AsianinBrazil:Dynamicsand
MolecularandPhylogeneticCharacterization
Beta?niaPaivaDrumond1*,AdrianoMondini2,DianeJ.Schmidt3,RobertaVieiradeMoraisBronzoni4,
IreneBosch5,Maur?′cioLacerdaNogueira6*
1Laborato′riodeVirologia,UniversidadeFederaldeJuizdeFora,JuizdeFora,MinasGerais,Brazil,2Laborato′riodeSau′dePu′blica,FaculdadedeCie?nciasFarmace?uticas,
Universidade Estadual Paulista, Araraquara, Sa?o Paulo, Brazil, 3Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts
University,NorthGrafton,Massachusetts,UnitedStatesofAmerica,4UniversidadeFederaldoMatoGrosso,Sinop,MatoGrosso,Brazil,5GenomeResourcesinDengue
Consortium,MassachusettsInstituteofTechnology.Cambridge,Massachusetts,UnitedStatesofAmerica,6Laborato′riodePesquisaemVirologia,FaculdadedeMedicina
deSa?o Jose′ doRioPreto(FAMERP),Sa?o Jose′ doRioPreto,Sa?o Paulo,Brazil
Abstract
The American/Asian genotypeof Dengue virus type 2 (DENV-2) was introduced into theAmericas in the 809s. Although
thereisnodatashowingwhenthisgenotypewasfirstintroducedintoBrazil,itwasfirstdetectedinBrazilin1990.After
whichthevirusspreadthroughoutthecountryandmajorepidemicsoccurredin1998,2007/08and2010.Inthisstudywe
sequenced12DENV-2genomesobtainedfromserumsamplesofpatientswithdenguefeverresidinginSa?o Jose′ doRio
Preto,Sa?o Paulo (SJRP/SP), Brazil, in 2008. The wholeopenreading frame orenvelope sequences were used toperform
phylogenetic, phylogeographic and evolutionary analyses. Isolates from SJRP/SP were grouped within one lineage (BR3)
closetoisolatesfromRiodeJaneiro,Brazil.IsolatesfromSJRPwereprobablyintroducedthereatleastin2007,priortoits
detection in the 2008 outbreak. DENV-2 circulation in Brazil is characterized by the introduction, displacement and
circulationofthreewell-definedlineagesindifferenttimes,mostprobablyfromtheCaribbean.Thirty-sevenuniqueamino
acid substitutions were observed among the lineages, including seve
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