Circulation of Dferent Lineages of Dengue Virus 2, Genotype AmericanAsian in Brazil Dynamics and Molecular and Phylogenetic Characterization.docVIP

Circulation of Dferent Lineages of Dengue Virus 2, Genotype AmericanAsian in Brazil Dynamics and Molecular and Phylogenetic Characterization.doc

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Circulation of Dferent Lineages of Dengue Virus 2, Genotype AmericanAsian in Brazil Dynamics and Molecular and Phylogenetic Characterization

CirculationofDifferentLineagesofDengueVirus2, GenotypeAmerican/AsianinBrazil:Dynamicsand MolecularandPhylogeneticCharacterization Beta?niaPaivaDrumond1*,AdrianoMondini2,DianeJ.Schmidt3,RobertaVieiradeMoraisBronzoni4, IreneBosch5,Maur?′cioLacerdaNogueira6* 1Laborato′riodeVirologia,UniversidadeFederaldeJuizdeFora,JuizdeFora,MinasGerais,Brazil,2Laborato′riodeSau′dePu′blica,FaculdadedeCie?nciasFarmace?uticas, Universidade Estadual Paulista, Araraquara, Sa?o Paulo, Brazil, 3Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine, Tufts University,NorthGrafton,Massachusetts,UnitedStatesofAmerica,4UniversidadeFederaldoMatoGrosso,Sinop,MatoGrosso,Brazil,5GenomeResourcesinDengue Consortium,MassachusettsInstituteofTechnology.Cambridge,Massachusetts,UnitedStatesofAmerica,6Laborato′riodePesquisaemVirologia,FaculdadedeMedicina deSa?o Jose′ doRioPreto(FAMERP),Sa?o Jose′ doRioPreto,Sa?o Paulo,Brazil Abstract The American/Asian genotypeof Dengue virus type 2 (DENV-2) was introduced into theAmericas in the 809s. Although thereisnodatashowingwhenthisgenotypewasfirstintroducedintoBrazil,itwasfirstdetectedinBrazilin1990.After whichthevirusspreadthroughoutthecountryandmajorepidemicsoccurredin1998,2007/08and2010.Inthisstudywe sequenced12DENV-2genomesobtainedfromserumsamplesofpatientswithdenguefeverresidinginSa?o Jose′ doRio Preto,Sa?o Paulo (SJRP/SP), Brazil, in 2008. The wholeopenreading frame orenvelope sequences were used toperform phylogenetic, phylogeographic and evolutionary analyses. Isolates from SJRP/SP were grouped within one lineage (BR3) closetoisolatesfromRiodeJaneiro,Brazil.IsolatesfromSJRPwereprobablyintroducedthereatleastin2007,priortoits detection in the 2008 outbreak. DENV-2 circulation in Brazil is characterized by the introduction, displacement and circulationofthreewell-definedlineagesindifferenttimes,mostprobablyfromtheCaribbean.Thirty-sevenuniqueamino acid substitutions were observed among the lineages, including seve

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