Comparison of the Intracellular Trafficking Itinerary of CTLA-4 Orthologues.docVIP

ComparisonoftheIntracellularTraffickingItineraryof CTLA-4Orthologues SatdipKaur,OmarS.Qureshi,DavidM.Sansom* TheMRCCentreforImmuneRegulation,SchoolofImmunityandInfection,UniversityofBirminghamMedicalSchool,Birmingham,UnitedKingdom Abstract CTLA-4 is an essential inhibitor of T cell immune responses. At steady state, most CTLA-4 resides in intracellular compartments due to constitutive internalisation mediated via a tyrosine based endocytic motif (YVKM) within the cytoplasmicdomain.Thisdomainishighlyconservedinmammalssuggestingstrongselectivepressure.Incontrast,theC- terminaldomainvariesconsi