Comparison of Profile Similarity Measures for Genetic Interaction Networks.docVIP

ComparisonofProfileSimilarityMeasuresforGenetic InteractionNetworks RaameshDeshpande,BenjaminVanderSluis,ChadL.Myers* DepartmentofComputerScienceandEngineering,UniversityofMinnesota-TwinCities,Minneapolis,Minnesota,UnitedStatesofAmerica Abstract Analysisofgeneticinteractionnetworksofteninvolvesidentifyinggeneswithsimilarprofiles,whichistypicallyindicativeof a common function. While several profile similarity measures have been applied in this context, they have never been systematicallybenchmarked.Wecomparedadiversesetofcorrelationmeasures,includingmeasurescommonlyusedby the genetic interact