Comparison of Two Voltage-Sensitive Dyes and Their Suitability for Long-Term Imaging of Neuronal Activity.docVIP

ComparisonofTwoVoltage-SensitiveDyesandTheir SuitabilityforLong-TermImagingofNeuronalActivity StephaniePreuss1¤,WolfgangStein2* 1InstituteofNeurobiology,UlmUniversity,Ulm,Germany,2SchoolofBiologicalSciences,IllinoisStateUniversity,Normal,Illinois,UnitedStatesofAmerica Abstract Oneofthekeyapproachesforstudyingneuralnetworkfunctionisthesimultaneousmeasurementoftheactivityofmany neurons.Voltage-sensitivedyes(VSDs)simultaneouslyreportthemembranepotentialofmultipleneurons,butoftenhave pharmacological and phototoxic effects on neuronal cells. Yet, to study the homeostatic processes that regulate n