Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases 英文论文文献.docVIP

Han et al. BMC Biochemistry 2010, 11:19 /1471-2091/11/19 RESEARCH ARTICLE Open Access Thermal stability, pH dependence and inhibition of Research article four murine kynurenine aminotransferases Qian Han1, Tao Cai2, Danilo A Tagle3 and Jianyong Li*1 Abstract Background: Kynurenine aminotransferase (KAT) catalyzes the transamination of kynunrenine to kynurenic acid (KYNA). KYNA is a neuroactive compound and functions as an antagonist of alpha7-nicotinic acetylcholine receptors and is the only known endogenous antagonist of N-methyl-D-aspartate receptors. Four KAT enzymes, KAT I/glutamin