Therapeutic targets for bone metastases in breast cancer 英文论文文献.docVIP

Clézardin Breast Cancer Research 2011,13:207 /content/13/2/207 RE VIE W Therapeutic targets for bone metastases in breast cancer Philippe Clézardin* 1,2 pathological fractures, hypercalcemia, nerve compression and loss of mobility [2]. Most of these patients will also experience substantial, life-altering cancer-induced bone Abstract Breast cancer is prone to metastasize to bone. Once metastatic cells are in the bone marrow, they do not, on their own, destroy bone. Instead, they alter the functions of bone-resorbing (osteoclasts) and bone-forming cells (osteoblasts), resulting in skelet