Thermodynamically consistent model calibration in chemical kinetics 英文论文文献.docVIP

JenkinsonandGoutsiasBMCSystemsBiology2011,5:64 /1752-0509/5/64 METHODOLOGY ARTICLE OpenAccess Thermodynamicallyconsistentmodelcalibration inchemicalkinetics GarrettJenkinsonandJohnGoutsias* Abstract Background:Thedynamicsofbiochemicalreactionsystemsareconstrainedbythefundamentallawsof thermodynamics,whichimposewell-definedrelationshipsamongthereactionrateconstantscharacterizingthese systems.Constructingbiochemicalreactionsystemsfromexperimentalobservationsoftenleadstoparameter valuesthatdonotsatisfythenecessarythermodynamicconstraints.Thiscanresultinmodelsthatarenot physicallyrealizableandm