Three-dimensional quantitative structure activity relationship (QSAR) of cytotoxic active 3,5-diaryl-4,5-dihydropyrazole analogs a comparative molecular field analysis (CoMFA) revisited study 英文论文文献.docVIP
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Three-dimensional quantitative structure activity relationship (QSAR) of cytotoxic active 3,5-diaryl-4,5-dihydropyrazole analogs a comparative molecular field analysis (CoMFA) revisited study 英文论文文献
HamadElgazwyetal.ChemistryCentralJournal2012,6:50
/content/6/1/50
RESEARCH ARTICLE
OpenAccess
Three-dimensionalquantitativestructureactivity
relationship(QSAR)ofcytotoxicactive3,5-diaryl-
4,5-dihydropyrazoleanalogs:acomparative
molecularfieldanalysis(CoMFA)revisitedstudy
Abdel-SattarSHamadElgazwy1*,DaliaHSSoliman2,SaadRAtta-Allah1andDiaaAIbrahim3
Abstract
Invitroantitumorevaluationofthesynthesized46compoundsof3,5-diaryl-4,5-dihydropyrazolesagainstEACcell
linesand3DQSARstudyusingpharmacophoreandComparativeMolecularFieldAnalysis(CoMFA)methodswere
described.CoMFAderivedQSARmodelshowsagoodconve
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