To bind or not to bind - FoxA1 determines estrogen receptor action in breast cancer progression 英文论文文献.docVIP

Watters et al. Breast Cancer Research 2012,14:312 /content/14/3/312 VIE WPOINT To bind or not to bind - FoxA1 determines estrogen receptor action in breast cancer progression Rebecca J Watters, Panayiotis V Benos and Ste? Oesterreich* of the ER cistrome in breast cancer cells [2]. By showing Abstract the following, the results brought an end to the dogma that ER binds primarily to the proximal promoters: (a) ER frequently binds distal enhancers [3], (b) the forkhead protein FoxA1 is necessary for ER-chromatin interactions [3-6], and (c) activation of GFR signaling resu