Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153 identification of genomic biomarkers of exposure to AhR ligands 英文论文文献.docVIP

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Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153 identification of genomic biomarkers of exposure to AhR ligands 英文论文文献.doc

Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153 identification of genomic biomarkers of exposure to AhR ligands 英文论文文献

Ovandoetal.BMCGenomics2010,11:583 /1471-2164/11/583 RESEARCH ARTICLE OpenAccess ToxicogenomicanalysisofexposuretoTCDD, PCB126andPCB153:identificationofgenomic biomarkersofexposuretoAhRligands BladimirJOvando1,CorieAEllison1,ChadMVezina2,JamesROlson1* Abstract Background:TwoyearcancerbioassaysconductedbytheNationalToxicologyProgramhaveshownchronic exposuretodioxin-likecompounds(DLCs)toleadtothedevelopmentofbothneoplasticandnon-neoplastic lesionsinthehepatictissueoffemaleSpragueDawleyrats.Most,ifnotall,ofthehepatotoxiceffectsinducedby DLC’sarebelievedtoinvolvethebindingandactivationofthetrans

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Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153 identification of genomic biomarkers of exposure to AhR ligands 英文论文文献.docVIP