TRAIL and vitamins opting for keys to castle of cancer proteome instead of open sesame 英文论文文献.docVIP
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TRAIL and vitamins opting for keys to castle of cancer proteome instead of open sesame 英文论文文献
Farooqietal.CancerCellInternational2012,12:22
/content/12/1/22
REVIEW
OpenAccess
TRAILandvitamins:optingforkeystocastleof
cancerproteomeinsteadofopensesame
AmmadAhmadFarooqi1*,ShahzadBhatti2andMuhammadIsmail3
Abstract
Cancerisamultifacetedmoleculardisorderthatismodulatedbyacombinationofgenetic,metabolicandsignal
transductionaberrations,whichseverelyimpairthenormalhomeostasisofcellgrowthanddeath.Accumulating
findingshighlightthefactthatdifferentgeneticalterations,suchasmutationsintumorsuppressorgenes,mightbe
relatedtodistinctanddifferentialsensitivitytotargetedtherapies.Itisbecomingincreasing
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