原创力文档Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells 英文论文文献.docVIP
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Transforming growth factor-β suppresses metastasis in a subset of human colon carcinoma cells 英文论文文献
Simmsetal.BMCCancer2012,12:221
/1471-2407/12/221
RESEARCH ARTICLE
OpenAccess
Transforminggrowthfactor-βsuppresses
metastasisinasubsetofhumancoloncarcinoma
cells
NekaA.K.Simms1?,AshwaniRajput2?,ElizabethASharratt3,MelanieOngchin4,CarolATeggart1,JingWang1
andMichaelGBrattain1*
Abstract
Background:TGFβsignalinghastypicallybeenassociatedwithsuppressionoftumorinitiationwhiletheroleit
playsinmetastasisisgenerallyassociatedwithprogressionofmalignancy.However,wepresentevidenceherefor
ananti-metastaticroleofTGFβsignaling.
Methods:TotesttheimportanceofTGFβsignalingtocellsurvivalandmetastasiswecompare
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