Trastuzumab-DM1 causes tumour growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo 英文论文文献.docVIP

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Trastuzumab-DM1 causes tumour growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo 英文论文文献.doc

Trastuzumab-DM1 causes tumour growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo 英文论文文献

Baroketal.BreastCancerResearch2011,13:R46 /content/13/2/R46 RESEARCH ARTICLE OpenAccess Trastuzumab-DM1causestumourgrowth inhibitionbymitoticcatastropheintrastuzumab- resistantbreastcancercellsinvivo MarkBarok1*,MinnaTanner1,2,KatriK?ninki1andJormaIsola1* Abstract Introduction:TrastuzumabiswidelyusedforthetreatmentofHER2-positivebreastcancer.Despiteencouraging clinicalresults,asignificantfractionofpatientsare,orbecome,refractorytothedrug.Toovercomethis, trastuzumab-DM1(T-DM1),anewer,morepotentdrughasbeenintroduced.Wetestedtheefficacyand mechanismsofactionofT-DM1innineHER2-positivebreastcanc

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Trastuzumab-DM1 causes tumour growth inhibition by mitotic catastrophe in trastuzumab-resistant breast cancer cells in vivo 英文论文文献.docVIP