Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion model 英文论文文献.docVIP
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Treatment with the C5a receptor antagonist ADC-1004 reduces myocardial infarction in a porcine ischemia-reperfusion model 英文论文文献
vanderPalsetal.BMCCardiovascularDisorders2010,10:45
/1471-2261/10/45
RESEARCH ARTICLE
OpenAccess
TreatmentwiththeC5areceptorantagonist
ADC-1004reducesmyocardialinfarctionina
porcineischemia-reperfusionmodel
JespervanderPals1,SashaKoul1,PatrikAndersson1,MatthiasG?tberg1,JoeyFAUbachs2,MikaelKanski2,
H?kanArheden2,G?ranKOlivecrona1,BengtLarsson3,4,DavidErlinge1*
Abstract
Background:Polymorphonuclearneutrophils,stimulatedbytheactivatedcomplementfactorC5a,havebeen
implicatedincardiacischemia/reperfusioninjury.ADC-1004isacompetitiveC5areceptorantagonistthathasbeen
showntoinhibitcomplementrelatedn
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