Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment 英文论文文献.docVIP
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Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment 英文论文文献
Luetal.CardiovascularDiabetology2013,12 :28
/content/12/1/28
CARDIO
VASCULAR
DIABETOLOGY
ORIGINAL INVESTIGATION
OpenAccess
Treatmentwithacopper-selectivechelatorcauses
substantiveimprovementincardiacfunctionof
diabeticratswithleft-ventricularimpairment
JunLu1,8,BeauPontré3,4,StephenPickup7,SoonYChoong1,MingmingLi1,HongXu9,GregoryDGamble5,
AnthonyRJPhillips1,2,6,BrettRCowan3,4,AlistairAYoung3,4andGarthJSCooper1,2,10,11,12*
Abstract
Background:Defectivecopperregulationisimplicatedasacausativemechanismoforgandamageindiabetes.
Treatmentwithtrientine,adivalent-copper-selectivechelator,improvesa
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