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Ultrahigh-dimensional variable selection method for whole-genome gene-gene interaction analysis 英文论文文献
UekiandTamiyaBMCBioinformatics2012,13:72
/1471-2105/13/72
METHODOLOGY ARTICLE
OpenAccess
Ultrahigh-dimensionalvariableselectionmethod
forwhole-genomegene-geneinteractionanalysis
MasaoUeki*?andGenTamiya?
Abstract
Background:Genome-widegene-geneinteractionanalysisusingsinglenucleotidepolymorphisms(SNPs)isan
attractivewayforidentificationofgeneticcomponentsthatconferssusceptibilityofhumancomplexdiseases.
IndividualhypothesistestingforSNP-SNPpairsasincommongenome-wideassociationstudy(GWAS)however
involvesdifficultyinsettingoverallp-valueduetocomplicatedcorrelationstructure,namely,themultiplete
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