原创力文档Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression 英文论文文献.docVIP
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Valproic acid decreases urothelial cancer cell proliferation and induces thrombospondin-1 expression 英文论文文献
Byleretal.BMCUrology2012,12:21
/1471-2490/12/21
RESEARCH ARTICLE
OpenAccess
Valproicaciddecreasesurothelialcancercell
proliferationandinducesthrombospondin-1
expression
TimothyKByler1,DeanLeocadio1,OlegShapiro1,GennadyBratslavsky1,ChristopherJStodgell2,RonaldWWood2,
EdwardMMessing3andJayEReeder1,2*
Abstract
Background:Preventionofbladdercancerrecurrenceisacentralchallengeinthemanagementofthishighly
prevalentdisease.Thehistonedeacetylaseinhibitorvalproicacid(sodiumvalproate)hasanti-angiogenicproperties
andhasbeenshowntodecreasebladdercancergrowthinmodelsystems.Wehavepreviouslyshownreduced
ex
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