Variations in Mre11Rad50Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel 英文论文文献.docVIP

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Variations in Mre11Rad50Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel 英文论文文献.doc

Variations in Mre11Rad50Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel 英文论文文献

GarnerandEastmanBMCCancer2011,11:206 /1471-2407/11/206 RESEARCH ARTICLE OpenAccess VariationsinMre11/Rad50/Nbs1statusandDNA damage-inducedS-phasearrestinthecelllines oftheNCI60panel KristenMGarnerandAlanEastman* Abstract Background:TheMre11/Rad50/Nbs1(MRN)complexisaregulatorofcellcyclecheckpointsandDNArepair. DefectsinMRNcanleadtodefectiveS-phasearrestwhencellsaredamaged.Suchdefectsmayelicitsensitivityto selecteddrugsprovidingachemicalsyntheticlethalinteractionthatcouldbeusedtotargettherapytotumors withthesedefects.ThegoalofthisstudywastoidentifythesedefectsintheNCI60panelofcelllinesandiden

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Variations in Mre11Rad50Nbs1 status and DNA damage-induced S-phase arrest in the cell lines of the NCI60 panel 英文论文文献.docVIP