原创力文档VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment 英文论文文献.docVIP
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VEGFR2 heterogeneity and response to anti-angiogenic low dose metronomic cyclophosphamide treatment 英文论文文献
Pattenetal.BMCCancer2010,10:683
/1471-2407/10/683
RESEARCH ARTICLE
OpenAccess
VEGFR2heterogeneityandresponseto
anti-angiogeniclowdosemetronomic
cyclophosphamidetreatment
StevenGPatten,UnaAdamcic,KristenLacombe,KanwalMinhas,KarolinaSkowronski,BrendaLCoomber*
Abstract
Background:Targetingtumorvasculatureisastrategywithgreatpromiseinthetreatmentofmanycancers.
However,anti-angiogenicreagentsthattargetVEGF/VEGFR2signalinghavemetwithvariableresultsclinically.
Amongthepossiblereasonsforthismaybeheterogeneousexpressionofthetargetprotein.
Methods:Doubleimmunofluorescentstainingwasperformedonformalin
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